Der Lesesaal im Wandel: Benchmarking zwischen fünf Medizinbibliotheken und Evaluation des Umbaus der Bibliothek Medizin in Bern

Benchmarking zwischen fünf Medizinbibliotheken und Evaluation des Umbaus der Bibliothek Medizin in Ber

Halogen-bonded one-dimensional chains of functionalized ditopic bipyridines co-crystallized with mono-, di-, and triiodofluorobenzenes

A series of halogen-bonded (XB) discrete, one-dimensional (1D) linear and zigzag supramolecular architectures by co-crystalizing a sterically hindered class of homologous ditopic para-xylenes bearing bipyridyl moieties at peripheries with mono-, di-, and triiodofluorobenzene as XB donor components were prepared. The solid-state structures investigated by X-ray diffraction on single crystals show that the molecular geometry of the tectons and halogen bond directionality translates into corresponding XB co-crystals and display a conformational twist at the planes of para-xylene with the adjacent aromatic rings. The bipyridine tectons grafted with photo-responsive azobenzene (–N=N–) side-group, once integrated into the halogen-bonded chains, can be remotely modulated by light, thus being applicable for controlling structure and innovative applications possibilities

Substrate‐Bound Diarylethene‐Based Anisotropic Metal–Organic Framework Films as Photoactuators with a Directed Response

Molecular machines and responsive materials open a plethora of new opportunities in nanotechnology. We present an oriented crystalline array of diarylethene (DAE)-based photoactuators, arranged in a way to yield an anisotropic response. The DAE units are assembled, together with a secondary linker, into a monolithic surface-mounted metal–organic framework (SURMOF) film. By Infrared (IR) and UV/Vis spectroscopy as well as by synchrotron X-ray diffraction, we show that the light-induced extension changes of the molecular DAE linkers multiply to yield mesoscopic and anisotropic length changes. Due to the special architecture and substrate-bonding of the SURMOF, these length changes are transferred to the macroscopic scale, leading to the bending of a cantilever and performing work. This research shows the potential of assembling light-powered molecules into SURMOFs to yield photoactuators with a directed response, presenting a path to advanced actuators

Clinical Knowledge Platform (CKP): a collaborative ecosystem to share interoperable clinical forms, viewers, and order sets with various EMRs

International audienceA large number of Electronic Medical Records (EMR) are currently available with a variety of features and architectures. Existing studies and frameworks presented some solutions to overcome the problem of specification and application of clinical guidelines toward the automation of their use at the point of care. However, they could not yet support thoroughly the dynamic use of medical knowledge in EMRs according to the clinical contexts and provide local application of international recommendations. This study presents the development of the Clinical Knowledge Platform (CKP): a collaborative interoperable environment to create, use, and share sets of information elements that we entitled Clinical Use Contexts (CUCs). A CUC could include medical forms, patient dashboards, and order sets that are usable in various EMRs. For this purpose, we have identified and developed three basic requirements: an interoperable, inter-mapped dictionary of concepts leaning on standard terminologies, the possibility to define relevant clinical contexts, and an interface for collaborative content production via communities of professionals. Community members work together to create and/or modify, CUCs based on different clinical contexts. These CUCs will then be uploaded to be used in clinical applications in various EMRs. With this method, each CUC is, on the one hand, specific to a clinical context and on the other hand, could be adapted to the local practice conditions and constraints. Once a CUC has been developed, it could be shared with other potential users that can consume it directly or modify it according to their needs

Tunable molecular separation by nanoporous membranes

Metal-organic frameworks offer tremendous potential for efficient separation of molecular mixtures. Different pore sizes and suitable functionalizations of the framework allow for an adjustment of the static selectivity. Here we report membranes which offer dynamic control of the selectivity by remote signals, thus enabling a continuous adjustment of the permeate flux. This is realized by assembling linkers containing photoresponsive azobenzene-side-groups into monolithic, crystalline membranes of metal-organic frameworks. The azobenzene moieties can be switched from the trans to the cis configuration and vice versa by irradiation with ultraviolet or visible light, resulting in a substantial modification of the membrane permeability and separation factor. The precise control of the cis:trans azobenzene ratio, for example, by controlled irradiation times or by simultaneous irradiation with ultraviolet and visible light, enables the continuous tuning of the separation. For hydrogen:carbon-dioxide, the separation factor of this smart membrane can be steplessly adjusted between 3 and 8

Proton-conduction photomodulation in spiropyran-functionalized MOFs with large on–off ratio

Proton conduction in nanopores is important for applications in fuel cells, chemical sensors and information processing devices inspired by nature. Here, we present a nanoporous material, a metal–organic framework (MOF) thin film, allowing photomodulation of the aqueous and alcoholic proton conduction of the guests by almost two orders of magnitude. The MOF film possesses spiropyran groups which undergo reversible UV-light induced isomerization to the merocyanine form, a highly polar, zwitterionic molecule, where the strong binding of the guests to the merocyanine isomer efficiently suppresses the proton conduction. Such materials with photomodulated ionic conduction contribute to the development of advanced, remotecontrollable chemical sensors and to switchable devices interfacing with biological systems

Metal‐Organic Framework Thin Films as Ideal Matrices for Azide Photolysis in Vacuum

Studies on reactions in solutions are often hampered by solvent effects. In addition, detailed investigation on kinetics is limited to the small temperature regime where the solvent is liquid. Here, we report the in situ spectroscopic observation of UV-induced photochemical reactions of aryl azides within a crystalline matrix in vacuum. The matrices are formed by attaching the reactive moieties to ditopic linkers, which are then assembled to yield metal–organic frameworks (MOFs) and surface-mounted MOFs (SURMOFs). These porous, crystalline frameworks are then used as model systems to study azide-related chemical processes under ultrahigh vacuum (UHV) conditions, where solvent effects can be safely excluded and in a large temperature regime. Infrared reflection absorption spectroscopy (IRRAS) allowed us to monitor the photoreaction of azide in SURMOFs precisely. The in situ IRRAS data, in conjunction with XRD, MS, and XPS, reveal that illumination with UV light first leads to forming a nitrene intermediate. In the second step, an intramolecular rearrangement occurs, yielding an indoloindole derivative. These findings unveil a novel pathway for precisely studying azide-related chemical transformations. Reference experiments carried out for solvent-loaded SURMOFs reveal a huge diversity of other reaction schemes, thus highlighting the need for model systems studied under UHV conditions

Indexing grey multilingual literature in General Practice: Family medicine in the era of semantic web

peer reviewedProblem/Goal: Sharing the results of research with General Practitioners (GPs) is crucial for the survival of the discipline of General Practice / Family Medicine (GP/FM). The production of abstracts in GP/FM probably exceeds 15,000 per year worldwide. Each abstract often represents two years of work for its authors and is expressed in local languages. Only 45% of them are published in indexed medical journals. Usual indexing systems like MeSH are not multilingual nor adapted to the particular field of GP/FM. Consequently, these abstracts are lacking bibliographic control and more than half of the research presented by GPs at congresses is lost. Considering the absence of appropriate domain-specific terminologies or classification systems, we propose a new multilingual indexing system. The existing International Classification of Primary Care (ICPC) is currently used for clinical purposes and has now been expanded with a taxonomy related to contextual aspects (called Q-Codes) such as education, research, practice organization, ethics or policy in GP/FM, currently not captured. The set is proposed under the name Core Content Classification in General Practice (3CGP). The aim is to facilitate indexing of GP/FM specific scientific work and to improve performance in information storage and retrieval for research purposes in this field. Research Method/Procedure: Using qualitative analysis, a corpus of 1,702 abstracts from six GP/FM- related European congresses was analyzed to identify main themes discussed by GPs (e.g., continuity, accessibility or medical ethics), handled in a domain-specific taxonomy called Q-Codes and translated in 8 languages. In addition, a methodology for building a lightweight ontology (in OWL-2) was applied to Q-Codes, adding object and datatype properties to the hierarchical relations, including mapping to the MeSH thesaurus, Babelnet (www.babelnet.org) and Dbpedia. Finally, the Q-Codes in 8 languages have been integrated healthcare terminology service (www.hetop.eu/q) with a companion website (http://3cgp.docpatient.net). Anticipated Results of the Research: The creation and the on-line publication of this multilingual terminological resource, for indexing abstracts and for facilitating Medline searches, could reduce loss of knowledge in the domain. In addition, through better indexing of the grey literature (congress abstracts, master’s and doctoral thesis), we hope to enhance the accessibility of research results of GP/FM domain and promote the emergence of networks of researchers. First result of experimental implementations of the new indexing system will be presented. Indication of costs related to the project: This project has not been funded. 3CGP is placed under Attribution-Non-Commercial-Share-Alike 4.0 International (CC BY-NC-SA 4.0). ICPC is copyrighted by WONCA. © 2018 Oriental Scientific Publishing Company. All rights reserved